Depressive and neurotic behaviours have many potential triggers and contributory factors, but few associated genetic variants have been found, most likely due to the large numbers of subjects needed: Genome-Wide Association Studies (GWAS) require large sample sizes to have sufficient statistical power, which is often achieved by aggregating results in […]
Many people are aware of the concept that their blood group influences their interaction with the environment: intestinal secretions of blood group antigens affect a person’s interaction with foods through being a marker of self recognised by the immune system. Similar to the way that a transfusion of blood from […]
This is a current list of the multi-snp algorithms currently available in Opus 23. A few titles repeat, for the simple reason that two different algorithms, using different snps or genes, can result in a similar conclusion. Algorithms can be quite complex: it is not uncommon for one algorithm to […]
Opus 23 provides many unique opportunities for data integration and visualization. One app that I’ve just been added to the Opus toolbox is STROBE, a new Opus analytic app that allows you drill-down client genomic data by organ, tissue or cell distribution. To do this Opus mashes up its own […]
The Opus 23 PSYCHIC app allows you to search for natural products known to control gene expression. However, unlike a simple search engine, PSYCHIC is able to crawl up and down the molecular ‘Interactome’ (protein-protein interactions and gene expression data) to determine the upstream and downstream genes that interact with […]
The Agency app in Opus 23 takes pharmacogenomics to the next level. Relying on the extensive Opus 23 database of published research detailing gene expression data linked to natural products, Agency provides a visual representation of their interactions web. Multiple agents can be displayed, allowing the clinician to synthesis multi-target […]
SuperMogadon is a highly flexible search and sort tool that allows you to easily compare the client’s genotype with results from Genome Wide Association Studies* (GWAS) through the Opus 23 Pro database. As you can see there are over 50+ pages of GWAS data in SuperMogadon, which would make grinding […]
MoboCaster is an Opus 23 Pro informatics app that performs scenario-specific genomic analysis since, as clinicians, that’s pretty much how we think about genomics. The browser screen (above) in MoboCaster lists an overview of several genomic scenarios, such as the HPA Axis, Oxalate Genomics, Phase I Detoxification, etc. that display […]
There has been an explosion of interest in the microbiome. Outfits such as uBiome has made it relatively inexpensive and easy to have your microbiome profiled. These services extract the bacterial DNA out of the sample and identify each of the bacteria that the DNA came from. There appear to […]
Two years ago I developed a software app called SkySaw for use on my teaching shift at the COEGM. SkySaw allows clinicians to structure patient encounters as a linked network (technically a directed acyclic graph). What made this attractive was that these individual networks could be connected together into a great […]
