• Meet and greet Opus23 webinars!

    Starting in January 2018, we will begin hosting monthly webinars to showcase the powerful tools of Opus23. These webinars are completely FREE and will cover the basics of Opus23, discuss what sets us apart from other genomic analysis programs and provide a live demo of both Opus23 and Utopia. The first webinar will be held on January 9th at 11:00AM ET.

    The webinars are hosted by Dr. Robert Boyd, one of developers of Opus23, and chief resident at the Center of Excellence in Generative Medicine.

    These introductory webinars are best suited for individuals who are interested in learning about Opus23, but have not yet taken the training webinar. They will also serve as a great refresher for any users who have completed the Opus training in the past.

    A special discount offer will be provided to all attendees for an upcoming training webinar or client upload.

    Click here to register here for the webinar!

    Please share this post to anyone you know who would benefit from using Opus23 in their practice!

  • Opus 23 now supports multiple platforms

    The recent change in the reporting done by 23andMe from the V4 to V5 chip has thrown things into a bit of a dither. The earlier V4 SNP array was more robust, at least with SNPs of interest to those who work in nutrigenomics. For example, V4 reported over ten MAO SNPs of nutritional interest, whist V5 reports none. To circumvent the problem, I’ve recoded Opus 23 to allow the clinician to upload, singly or in combination, data files from 23andMe (V3, V4, V5), Ancestry DNA and the ‘Export to Promethease’ file available from Genos. To move Opus in this direction required a lot of recoding and I thank all our users for their support and patience.

    The first time you load an existing client profile into Opus it will take a bit longer to process the file. This is because they are being upgraded to the new data storage system. After that they should load as usual. Manage->Profiles->Append Raw Data to Current Client will take you to the BLENDER app,which allows you to merge raw data files. This will only be important as people begin to use Ancestry DNA, perhaps in combination with 23andMe V5. Since almost everyone currently in Opus is 23andMe V4 you really don’t need to do anything.

    The ‘Upload New Client Raw Data’ script has been extensively re-written. You still upload a ZIP file, but the script will identify the platform (V3/V4, V5, Ancestry DNA) and let you know. It also now features and extra screen so that you can verify/validate your form input before doing the final upload. Hopefully this will cut down on people contacting us having uploaded the same client twice.

    Uploading and merging  V5 and Ancestry DNA client data have about 74% of Opus-curated snps, while the prior V4 has about 79% coverage.

    If you do upload Ancestry DNA data, be advised that Ancestry names its raw data files in a non-unique manner, usually something like ‘’. This blunts the ability of the program to warn you that you are using the same data file on two different clients. You should rename the client raw data ZIP file on your hard drive to something unique (we recommend replacing Ancestry DNA filename with the client’s first and last initials and date of birth; in this case ‘’ might become ‘’ But you can use any system you wish as long as each uploaded filename is unique.

    It looks like the best short term solution will be to have the client do BOTH 23andme V5 and Ancestry.  Opus 23  now allows you to sequentially upload the raw data and merge it. We will eventually move towards a dedicated chip. However this change from v4 to v5 caught everyone (not just Opus/Datapunk) flat-footed as to the huge drop in clinically significant SNPs that are reported in v5. Even in the best of circumstances it will be weeks and months until a specialized chip will become available. However, in the meantime, piggybacking 23andMe v5 with Ancestry DNA appears to be not all that bad of a temporary fix. Many of these SNP panels are having significant price drops, so having the client do bot 23andMe V5 and Ancestry DNA should not be prohibitively expensive.


    In Other News

    You can now compare V5, V4, Genos Promethease export, and Ancestry data as compared to the core 2600 Opus snps. Just log in, click the ‘Informatics’ pull down, the select ‘Tools/ Extras’ and “Platform Comparisons’. Table is searchable, sortable and filterable.

  • Upcoming Opus 23 In-Person Seminar

    Because of media obligations associated with the re-release of Dr. D’Adamo’s first book, there is a schedule conflict with the January 7-8 seminar date. The seminar will be rescheduled for a later date.  Please check back for further news and details.

    If you are even thinking about doing this sign up.Opus 23 has been a game changer for my patients who have had ‘mysterious’ problems that, after seeing many integrative practitioners, still were not better until Opus 23 ‘sang’ the perfect healing words. –Robert Lang, MD

    Dr. D’Adamo periodically does these for those practitioners who prefer a more hands-on approach to learning Opus 23 (vs. the wonderful 5 hour webinars done by Drs. Greenfield).

    Dr. D’Adamo writes:

    ‘Attendees work in 2-3 person pods under the direct supervision of one of my COE wunderkids. You also get a healthy dose of me lecturing on stuff: In this case a heavy focus on the new ‘Utopia’ module that allows you to mash up client genomic and microbiome data. Attendance is purposely kept to 10-12, to insure an intimate learning environment. You get lunch and I typically spring for dinner at a nice restaurant.’

    If you are interested in this type of hands-on training, contact Carol Agostino at (203 761-0042) for full details.

  • Opus Training and Certification


    Thank you for this brilliant creation. I am honored to be a part of this game-changing program. –Robert Lang, MD

    Opus 23 Pro is designed to be as intuitive to use as it is powerful. However, mastery requires understanding and fully utilizing all the nuances of the many available apps in the program. For those who specialize in genomic testing and focus a large part of their practice on nutrigenomics, we are developing a weekend seminar intensive on Opus 23 mastery. Participants will work directly with Dr. Peter D’Adamo and his team of teaching assistants in a hands-on environment, using Opus 23 Pro to develop fully formatted and curated genomic reports. Attendees successfully completing the seminar will be certified as official Opus 23 consultants.

    photo: Bob Messineo
    photo: Bob Messineo

    The tentative dates for the next seminar are 8/20 – 8/21 at the Center of Excellence in Generative Medicine at the University of Bridgeport, in Bridgeport Connecticut.


    Because the seminar is designed to be experiential, seating is extremely limited. Please check back here for further details. Seating is on a first come, first served basis. You can soft-reserve seating (no obligation) by completing the form below. This seminar will not be recorded or available as a webinar. The total cost of the seminar is $850 USD and includes lunch on Saturday. All participants completing the seminar will have three (3) complimentary client licenses assigned to their account for their own future use ($210 USD value).

    Note: This seminar is open to all licensed professionals.

    International Professionals: we plan to do a similar seminar in London (UK) area sometime later in the year.

    I’m interested in attending the next Opus 23 Training Seminar.

    Please supply your professional qualifications (required)


    This has been a wonderful month for attending training and conferences and for reconnecting with so many friends and colleagues. The Opus Pro new software that Dr. D’Adamo designed is phenomenal! The software is cutting edge and user friendly. Those of us that attended the CT training now have access to software that analyzes SNPs (genetic variations) and helps identify important patterns for current and predisposed health conditions. Wow!!!

    Ivory Raye, ND

  • Don’t Fall into the Methyl Trap!

    Methyl trapping is a situation in which folate becomes trapped and unusable by the body. It is defined as a functional folate deficiency that alters homocysteine metabolism such that folatedependent resynthesis of methionine is compromised.

    Methyl trapping was originally described in Downs Syndrome (trisomy 21) where plasma levels of homocysteine, methionine, S-adenosylhomocysteine and S-adenosylmethionine were all significantly decreased, suggesting a depression in cellular methylation capacity.  Elevated transsulfation activity with depletion of glutathione was also observed in Downs Syndrome due to the presence of an additional CBS allele, and up-regulated chromosome 21 SOD SNPs causing oxidative stress.(1)

    DS HcyThe term methyl trapping is now applied to the cascade of symptoms of neuroexcitation following supplementation with folate,  or B12 or SAMe as a first line treatment for MTHFR SNPs. The unassuming consumer who takes supplements with methylating B vitamins may experience varying degrees of neurotoxic symptoms manifested as apparently unprovoked insomnia, rage, anxiety, brain fog and alcohol intolerance (induced sulfite and aldehyde toxicity), often after experiencing a brief period of improvement from low energy and cognitive impairment.

    Methylation ModulationLow energy and irritability occur because of a dysregulation within the methionine cycle due to one-carbon metabolism SNPcausing an accumulation of Homocysteine Pathwaymethyl compounds often complicating histamine degradation. A build up of homocysteine is the consequence, often worsened by a bottleneck at CBS (cystathionine beta synthase) due to down-regulating SNPs in the homocysteine clearing transsulfation pathway.

    Neuroexcitatory and depression symptoms ensue from the complication of BH2-BH4 pathway reversal, resulting in incomplete ammonia-clearing by the urea cycle and reduced neurotransmitter formation.BH4-Chart3

    SNPs in MAO and COMT reduce degradation and transporter protein SNPs contribute to dopamine-serotonin imbalance.(2) Patients can also experience poor wound healing, aggravated digestive symptoms of bloating, alternating constipation and diarrhoea, or worsened IBS as a result of reduced methylation capacity.

    Clinicians should screen for conditions that may overwhelm transsulfation and detoxification pathways including infection, autoimmunity, toxic body burden, problems with blood sugar and fat metabolism and other inflammatory indications. Non-methylating nutritional support should be provided for mutations in MTR/MTRR, BHMT, SHMT2, MAT1A, CBS, QDPR, OTC, CPS, ARG2, PCBD1, MAOA or B, COMT, HNMT, DHPR, NOS1, 2, 3, SOD1, SOD2, PEMT, PON1, ABCB1, cytochrome P 450 genes and Soluble Carrier Family transporter protein SNPs, ACAT1-02, in deciding when to support Methylation cycle SNPs.

    Methyl trapping at a glance:

    Practitioners can use cutting-edge cloud-based software curated by naturopathic physicians. Mobocaster is a cutting edge application in Opus23 Pro offering the practitioner scenario-specific genetic analysis including power factors and relevant descriptions.


    1. Pogribna M, Melnyk S, Pogribny I, Chango A, Yi P, James SJ. Homocysteine
      metabolism in children with Down syndrome: in vitro modulation. Am J Hum Genet.
      2001 Jul;69(1):88-95. PMID: 11391481.
    2. Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals.
      Semin Thromb Hemost. 2000;26(3):219-25. Review. PMID: 11011839.