{"id":509,"date":"2016-11-17T08:51:29","date_gmt":"2016-11-17T13:51:29","guid":{"rendered":"http:\/\/datapunk.net\/opus23blog\/?p=509"},"modified":"2021-05-12T09:05:56","modified_gmt":"2021-05-12T13:05:56","slug":"utopia-advice-intelligent-interface-with-opus23","status":"publish","type":"post","link":"https:\/\/datapunk.net\/opus23blog\/2016\/11\/17\/utopia-advice-intelligent-interface-with-opus23\/","title":{"rendered":"Utopia: Advice, Intelligent interface with Opus23"},"content":{"rendered":"
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Advice: Intelligent Interface with OPUS23<\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

ADVICE is an app in Utopia that gives algorithmic considerations of multiple bacterial strains in conjunction with the client’s own genome to provide true\/false clinical outcomes. ADVICE automatically pulls the client\u2019s Opus23 genetic data where relevant, and incorporates it into algorithmic calculations. (comparable to LUMEN in Opus23<\/a>).<\/p>\n

Getting around ADVICE<\/h3>\n

From the Utopia drop down menu, hover over \u2018Algorithms\u2019 until a second list appears, then select \u2018Advice\u2019. You are presented with a list of algorithms, those that are true are at the top and display the word \u2018TRUE\u2019 in a green box, followed by those that are false, which display the word \u2018FALSE\u2019 in an orange box. Each algorithm will display the repute (risk, benefit or neutral), and the magnitude. If an algorithm suggests prescriptive metabolites which enhance or reduce specific bacteria, they will be listed under Encourage or Discourage.<\/p>\n

The client\u2019s relevant genes will be displayed beneath the listed \u2018microbiota\u2019 information in the same format found in the Opus23 LUMEN app. Clicking on the colored semicircle will open a pop-up window with a description of the gene and giving details of the client\u2019s SNPs for the gene from their Opus23 data.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\"Utopia<\/p>\n

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An ADVICE algorithm for gluten-induced immunopathology<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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All metabolites and taxa are clickable. Clicking a metabolite opens a pop-up window with a list of bacteria affected by it. Clicking a bacterium opens a pop-up window as described in previous apps. To add an algorithm to the client report, click on the \u2018Add\/ Uncurated\u2019 button.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Individual genera may also be curated and added to the client report for the current dataset by selecting the taxon to open its pop-up information and then clicking the \u2018Add\/Uncurated’ button.<\/p>\n

\"Screen<\/p>\n<\/div>\n

Pop-up window in ADVICE showing metabolomics information<\/p>\n

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Using the Algorithm Aggregate Analysis<\/h3>\n

At the bottom of the page is the Algorithm Aggregate Analysis. This is a summary of all advice for the client listed under either an \u2018increase\u2019 and \u2018decrease\u2019 section heading. Each section provides both the microbiota and beneficial\/ harmful metabolites that are suggested to be increased or decreased by your client. The \u2018result\u2019 information can be a useful tool for streamlining complex treatment strategies. Each metabolite listed in the Algorithm Aggregate Analysis details whether or not the metabolite has mixed results (included as both encourage and discourage in ADVICE algorithms), and whether it is specific to an algorithm.<\/p>\n<\/div>\n

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\"Algorithm<\/p>\n

Algorithm Aggregate Analysis for the ADVICE app<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\"Facebook\"<\/a>\"twitter\"<\/a>\"reddit\"<\/a>\"pinterest\"<\/a>\"linkedin\"<\/a>\"mail\"<\/a>","protected":false},"excerpt":{"rendered":"

Advice: Intelligent Interface with OPUS23 ADVICE is an app in Utopia that gives algorithmic considerations of multiple bacterial strains in conjunction with the client’s own genome to provide true\/false clinical outcomes. ADVICE automatically pulls the client\u2019s Opus23 genetic data where relevant, and incorporates it into algorithmic calculations. (comparable to LUMEN […]<\/p>\n","protected":false},"author":2,"featured_media":481,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,5,8,38],"tags":[44,31,39],"class_list":["post-509","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-apps","category-client-reporting","category-help-docs","category-utopia","tag-advice","tag-algorithm","tag-utopia"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts\/509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/comments?post=509"}],"version-history":[{"count":5,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts\/509\/revisions"}],"predecessor-version":[{"id":924,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts\/509\/revisions\/924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/media\/481"}],"wp:attachment":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/media?parent=509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/categories?post=509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/tags?post=509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}