{"id":244,"date":"2016-02-20T04:23:18","date_gmt":"2016-02-20T09:23:18","guid":{"rendered":"http:\/\/datapunk.net\/opus23blog\/?p=244"},"modified":"2021-05-12T09:15:19","modified_gmt":"2021-05-12T13:15:19","slug":"dont-fall-into-the-methyl-trap","status":"publish","type":"post","link":"https:\/\/datapunk.net\/opus23blog\/2016\/02\/20\/dont-fall-into-the-methyl-trap\/","title":{"rendered":"Don’t Fall into the Methyl Trap!"},"content":{"rendered":"

Methyl t<\/span>rapping is a situation in which folate becomes trapped and unusable by the body. It is<\/span> defined as a <\/span>functional folate deficiency that alters homocysteine metabolism such that folate–<\/span>dependent resynthesis of methionine is compromised.<\/p>\n

Methyl trapping\u00a0was originally described in Downs Syndrome (<\/span>trisomy 21)<\/span> where plasma levels of homocysteine, methionine, S-adenosylhomocysteine and S-adenosylmethionine were all significantly decreased,<\/span> suggesting a depression in cellular methylation capacity.\u00a0 Elevated transsulfation activity with depletion of glutathione\u00a0was also observed in Downs Syndrome<\/span> due to the presence of<\/span> an additional CBS allele,<\/span> and up-regulated chromosome 21 SOD SNPs causing oxidative stress.(1)<\/span><\/p>\n

The term<\/span> m<\/span>ethyl trapping is now applied to the cascade of symptoms of neuroexcitation following <\/span>supplementation with folate,<\/span>\u00a0 <\/span>or B12 or SAMe as a first line treatment for MTHFR SNPs. The unassuming consumer who takes <\/span>supplements with methylating B vitamins may <\/span>experience varying degrees of neurotoxic symptoms manifested as apparently unprovoked insomnia, rage, anxiety, brain fog and alcohol intolerance (induced sulfite and aldehyde toxicity), often<\/span> after experiencing a brief period of improvement from<\/span>\u00a0low energy and cognitive impairment.<\/p>\n

\"MethylationLow energy and irritability\u00a0occur because of\u00a0a\u00a0dysregulation within the methionine cycle due to one-carbon metabolism SNPs\u00a0<\/span>causing an accumulation of \"Homocysteinemethyl compounds often complicating histamine degradation. A build up of homocysteine\u00a0is the consequence, often worsened by a bottleneck at CBS (cystathionine beta synthase) due to down-regulating SNPs in the homocysteine clearing transsulfation pathway.<\/p>\n

Neuroexcitatory and depression symptoms ensue from the complication of BH2-BH4 pathway reversal, resulting in incomplete ammonia-clearing by the urea cycle and reduced\u00a0neurotransmitter formation.\"BH4-Chart3\"<\/p>\n

SNPs in MAO and COMT reduce degradation and transporter protein SNPs contribute to dopamine-serotonin imbalance.(2) Patients can also experience poor wound <\/span>healing, aggravated digestive symptoms of bloating, alternating constipation and diarrhoea, or <\/span>worsened IBS as a result of reduced methylation capacity.<\/p>\n

Clinicians should screen for conditions that may overwhelm transsulfation and detoxification pathways including infection, autoimmunity,\u00a0toxic <\/span>body burden, problems with blood sugar and fat metabolism and other inflammatory indications.<\/span>\u00a0Non-methylating nutritional support should be provided<\/span> for mutations in MTR\/MTRR, BHMT, SHMT2, MAT1A, CBS, QDPR, OTC, CPS, ARG2, PCBD1, MAOA or B, COMT, HNMT, DHPR, NOS1, 2, 3, SOD1, SOD2, PEMT, PON1, ABCB1, cytochrome P 450 genes and Soluble Carrier Family transporter protein\u00a0SNPs, ACAT1-02, in deciding when to\u00a0support\u00a0<\/span>Methylation cycle SNPs.<\/p>\n

Methyl trapping at a glance: <\/span><\/strong><\/p>\n

Practitioners can use cutting-edge\u00a0cloud-based software curated by naturopathic physicians.\u00a0Mobocaster<\/a>\u00a0is a cutting edge application in Opus23 Pro offering the practitioner scenario-specific genetic analysis including power factors and relevant descriptions.<\/span><\/p>\n

References:<\/strong><\/p>\n

    \n
  1. Pogribna M, Melnyk S, Pogribny I, Chango A, Yi P, James SJ. Homocysteine
    \nmetabolism in children with Down syndrome: in vitro modulation. Am J Hum Genet.
    \n2001 Jul;69(1):88-95.     PMID: 11391481<\/a>.<\/li>\n
  2. Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals.
    \nSemin Thromb Hemost. 2000;26(3):219-25. Review.\u00a0    PMID: 11011839<\/a>.<\/li>\n<\/ol>\n\"Facebook\"<\/a>\"twitter\"<\/a>\"reddit\"<\/a>\"pinterest\"<\/a>\"linkedin\"<\/a>\"mail\"<\/a>","protected":false},"excerpt":{"rendered":"

    Methyl trapping is a situation in which folate becomes trapped and unusable by the body. It is defined as a functional folate deficiency that alters homocysteine metabolism such that folate–dependent resynthesis of methionine is compromised. Methyl trapping\u00a0was originally described in Downs Syndrome (trisomy 21) where plasma levels of homocysteine, methionine, […]<\/p>\n","protected":false},"author":9,"featured_media":919,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,8,10,11],"tags":[],"class_list":["post-244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-client-reporting","category-help-docs","category-news","category-training"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts\/244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/comments?post=244"}],"version-history":[{"count":32,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts\/244\/revisions"}],"predecessor-version":[{"id":942,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/posts\/244\/revisions\/942"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/media\/919"}],"wp:attachment":[{"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/media?parent=244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/categories?post=244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/datapunk.net\/opus23blog\/wp-json\/wp\/v2\/tags?post=244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}