Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs5065

Hard Link
rs5065 is a snp on gene NPPA (natriuretic peptide A)

GeneNPPA Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation Clinical significance Orientation (dbSNP) - (negative/reverse strand)
Gene Function
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1.
Pharmacogenomics
Amlodipine (AA): Those with the rs5065(AA) had more favorable cardiovascular disease outcomes if given amlodipine than if treated with chlorthalidone (diuretic)
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

NOT CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs1024611 () | rs3024496 () | Rs2660 () | rs1800896 (IL10) | rs2069705 () | rs4684847 () | rs1799964 () | rs5743594 () | rs5743795 () | rs5743551 () | rs622502 ()

MOST FREQUENTLY SEARCHED:
rs429358 (APOE) | rs9939609 (FTO) | rs1801181 (CBS) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs2187668 (HLA-DQA1) | rs4680 (COMT) | rs6025 (F5) | rs20541 (IL13) | rs2569191 (CD14) | rs2235544 (DIO1)








LURP ™ IS A REGISTERED TRADEMARK ® OF DATAPUNK BIOINFORMATICS, LLC. COPYRIGHT © 2015, 2016, 2017, 2018, 2019, 2020 ALL RIGHTS RESERVED.    |    DEVELOPER BLOG     |